3-Amino-α,α-dimethyl-3-phenyl-1-piperidineacetonitrile → HCID 59438452, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 100 mg (0.411 mmol) rac-2-(3-Amino-3-phenyl-piperidin-1-yl)-2-methyl-propionitrile in 2.0 ml tetrahydrofuran over mol-sieve at 0° C. under nitrogen, was added dropwise 1.4 ul (4.11 mmol) of a 3M methylmagnesium bromide solution in diethyl ether. The mixture was stirred at 0° C. for 10 minutes, and then at 60° C. for 30 hours. The mixture was cooled in an ice bath and quenched with a saturated ammonium chloride solution. The mixture was extracted 3 times with ethyl acetate. The combined extracts were dried over sodium sulfate, filtered and concentrated in vacuo to provide 60 mg (63%) of the title compound as a yellow gum. MS (m/e): 233.2 (M+H).

Provenance & Evidence