Sodium Carbonate → 5-(Trifluoromethyl)biphenyl-2-carboxylic acid

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A mixture of 300 mg (0.949 mmol) 2-iodo-4-trifluoromethyl-benzoic acid (CAS: 54507-44-7), 239 mg (1.898 mmol) phenylboronic acid, 302 mg (2.847 mmol) sodium carbonate and 10.7 mg (0.0475 mmol) palladium acetate in 4.5 ml water was stirred at room temperature for 48 hours. The mixture was filtered and the filtrate was acidified with 37% HCl. The mixture was stirred at room temperature for 30 minutes. The solid was filtered, washed with water and dried to provide 225 mg (89%) of the title compound as a brown solid. MS (m/e): 264.9 (M+H+)

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