Sodium Hydroxide → 2-Cyclobutyl-4-trifluoromethyl-benzoic acid

HRID 2177516Notes

Reaction equation

HRID 2177516 reaction equation
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1I.[Br-].[CH:17]1([Zn+])[CH2:20][CH2:19][CH2:18]1.[OH-].[Na+]>>[CH:17]1([C:5]2[CH:6]=[C:7]([C:10]([F:13])([F:12])[F:11])[CH:8]=[CH:9][C:4]=2[C:3]([OH:2])=[O:15])[CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 59438424Methyl 2-iodo-4-(trifluoromethyl)benzoateHCID 178419766HCID 178419766, compound

Product 1

HCID 594384322-Cyclobutyl-4-trifluoromethyl-benzoic acid

Procedure

In analogy to the procedure described for the synthesis of example B.10, the title compound was prepared from 2-iodo-4-trifluoromethyl-benzoic acid methyl ester and cyclobutyl zinc bromide followed by saponification with sodium hydroxide. MS (m/e): 243.0 (M−H)

Workup

  1. customIn analogy to the procedure described for the synthesis of example B.10

Sources & evidence

ORD record
ord-6a6fc44baf1148e1aaf0eff4df27cbe5
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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