2-Ethyl-4-(trifluoromethyl)benzoic acid → HCID 68477875, compound

HRID 2177528Notes

Reaction equation

HRID 2177528 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][C:4]([NH2:15])([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:3]1.[CH2:16]([C:18]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:19]=1[C:20](O)=[O:21])[CH3:17]>>[CH3:1][N:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][C:4]([NH:15][C:20](=[O:21])[C:19]2[CH:23]=[CH:24][C:25]([C:27]([F:28])([F:29])[F:30])=[CH:26][C:18]=2[CH2:16][CH3:17])([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 534060122-Ethyl-4-(trifluoromethyl)benzoic acidHCID 68477925HCID 68477925, compound

Product 1

HCID 68477875HCID 68477875, compound

Procedure

In analogy to the procedure described for the synthesis of example 1, the title compound was prepared from (3RS,5SR)-1,5-Dimethyl-3-phenyl-piperidin-3-ylamine (Example A.20) and 2-Ethyl-4-trifluoromethyl-benzoic acid (CAS: 854531-63-8). MS (m/e): 405.4 (M+H).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 1

Sources & evidence

ORD record
ord-21642d51d795478896c6240f43a2c7f6
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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