2-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride → HCID 59438418, compound

HRID 2177532Notes

Reaction equation

HRID 2177532 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][C:13]([NH2:23])([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:34]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:32]=[C:31]([C:39]([F:42])([F:41])[F:40])[C:27]=1[C:28](Cl)=[O:29]>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][C:13]([NH:23][C:28](=[O:29])[C:27]2[C:31]([C:39]([F:41])([F:42])[F:40])=[CH:32][C:33]([C:35]([F:36])([F:37])[F:38])=[CH:34][C:26]=2[O:25][CH3:24])([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 179993452-Methoxy-4,6-bis(trifluoromethyl)benzoyl chlorideHCID 59438461HCID 59438461, compound

Product 1

HCID 59438418HCID 59438418, compound

Procedure

In analogy to the procedure described for the synthesis of example 16, the title compound was prepared from rac-3-amino-3-phenyl-piperidine-1-carboxylic acid benzyl ester and 2-methoxy-4,6-bis-trifluoromethyl-benzoyl chloride (CAS: 886503-47-5).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 16

Sources & evidence

ORD record
ord-06622c7561ff42ebbb0586452c9d75c8
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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