HCID 59438461, compound → HCID 46848763, compound

HRID 2177536Notes

Reaction equation

HRID 2177536 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][C:13]([NH2:23])([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12]1)=O)C1C=CC=CC=1.[CH:24]1([C:27]2[CH:35]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:33]=[CH:32][C:28]=2[C:29](O)=[O:30])[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[CH:35]=[C:34]([C:36]([F:37])([F:38])[F:39])[CH:33]=[CH:32][C:28]=2[C:29]([NH:23][C:13]2([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:14][CH2:15][CH2:16][NH:11][CH2:12]2)=[O:30])[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 59438461HCID 59438461, compoundHCID 594384852-Cyclopropyl-4-(trifluoromethyl)benzoic acid

Product 1

HCID 46848763HCID 46848763, compound

Procedure

In analogy to the procedure described for the synthesis of example 29, the title compound was prepared from rac-3-amino-3-phenyl-piperidine-1-carboxylic acid benzyl ester and 2-cyclopropyl-4-trifluoromethyl-benzoic acid (Example B.3). MS (m/e): 389.1 (MH+).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 29

Sources & evidence

ORD record
ord-08c7978db22a409bb1051cc6b3bef9e6
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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