HRID2177537

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID59438461

未命名化合物

HCID59438501

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccccc2)CCCN(C(=O)OCc2ccccc2)C1

HCID59438534

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of example 16, the title compound was prepared from rac-3-amino-3-phenyl-piperidine-1-carboxylic acid benzyl ester (example 29, step 1) and 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride (Example B.6).

WORKUP

后处理

customIn analogy to the procedure described for the synthesis of example 16

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-31724d96f3974d8a95b5c695ab278288
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09067911B2
来源说明: uspto-grants-2015_06

反应 SMILES

[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][C:13]([NH2:23])([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:34]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:32]=[C:31]([S:39][CH3:40])[C:27]=1[C:28](Cl)=[O:29]>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][C:13]([NH:23][C:28](=[O:29])[C:27]2[C:31]([S:39][CH3:40])=[CH:32][C:33]([C:35]([F:38])([F:36])[F:37])=[CH:34][C:26]=2[O:25][CH3:24])([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1