2-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride → HCID 59438419, compound

HRID 2177538Notes

Reaction equation

HRID 2177538 reaction equation
[CH3:1][O:2][CH2:3][O:4][CH:5]1[CH2:10][N:9]([CH3:11])[CH2:8][C:7]([NH2:18])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6]1.[CH3:19][O:20][C:21]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([S:34][CH3:35])[C:22]=1[C:23](Cl)=[O:24]>>[CH3:19][O:20][C:21]1[CH:29]=[C:28]([C:30]([F:31])([F:32])[F:33])[CH:27]=[C:26]([S:34][CH3:35])[C:22]=1[C:23]([NH:18][C:7]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH:5]([O:4][CH2:3][O:2][CH3:1])[CH2:10][N:9]([CH3:11])[CH2:8]1)=[O:24]

Participants

3

Reactant 2

HCID 594385012-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chlorideHCID 59438531HCID 59438531, compound

Product 1

HCID 59438419HCID 59438419, compound

Procedure

In analogy to the procedure described for the synthesis of example 16, the title compound was prepared from rac-5-methoxymethoxy-1-methyl-3-phenyl-piperidin-3-ylamine (Example A.10) and 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride (Example B.6).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 16

Sources & evidence

ORD record
ord-d0aedf9fcf0b4f59880126723c4bfc30
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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