HCID 59438499, compound → HCID 59438492, compound

HRID 2177541Notes

Reaction equation

HRID 2177541 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][C:4]([NH2:14])([CH:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH2:3]1.[CH3:15][O:16][C:17]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([S:30][CH3:31])[C:18]=1[C:19](Cl)=[O:20]>>[CH3:15][O:16][C:17]1[CH:25]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:23]=[C:22]([S:30][CH3:31])[C:18]=1[C:19]([NH:14][C:4]1([CH:8]2[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[CH2:5][CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]1)=[O:20]

Participants

3

Reactant 2

HCID 59438499HCID 59438499, compoundHCID 594385012-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride

Product 1

HCID 59438492HCID 59438492, compound

Procedure

In analogy to the procedure described for the synthesis of example 16, the title compound was prepared from rac-1-methyl-3-(tetrahydro-pyran-4-yl)-piperidin-3-ylamine (Example A.12) and 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride (Example B6). MS (m/e): 447.2 (MH+).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 16

Sources & evidence

ORD record
ord-6df4091599724c6a95c1b0c7c04fd4db
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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