2-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride → HCID 59438443, compound

HRID 2177542Notes

Reaction equation

HRID 2177542 reaction equation
Cl.Cl.[CH3:3][N:4]1[CH2:9][CH2:8][CH2:7][C:6]([NH2:11])([CH3:10])[CH2:5]1.[CH3:12][O:13][C:14]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19]([S:27][CH3:28])[C:15]=1[C:16](Cl)=[O:17]>>[CH3:3][N:4]1[CH2:9][CH2:8][CH2:7][C:6]([NH:11][C:16](=[O:17])[C:15]2[C:19]([S:27][CH3:28])=[CH:20][C:21]([C:23]([F:26])([F:24])[F:25])=[CH:22][C:14]=2[O:13][CH3:12])([CH3:10])[CH2:5]1

Participants

3

Reactant 2

HCID 594385012-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chlorideHCID 68482015HCID 68482015, compound

Product 1

HCID 59438443HCID 59438443, compound

Procedure

In analogy to the procedure described for the synthesis of example 16, the title compound was prepared from rac-1,3-dimethyl-piperidin-3-ylamine dihydrochloride (Example A.13) and 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride (Example B6). MS (m/e): 377.3 (MH+).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 16

Sources & evidence

ORD record
ord-69a9da546f0a4f169e70e9a42694c76f
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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