2-Bromo-5-fluoropyridine → 1-(Pyrimidin-2-yl)-1H-imidazo[4,5-c]pyridine

HRID 2177550Notes

Reaction equation

HRID 2177550 reaction equation
F[C:2]1[CH:3]=C[C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N:13]=[CH:12][C:11]=3[N:10]=[CH:9]2)=[N:6][CH:7]=1.BrC1C=CC(F)=C[N:19]=1>>[N:6]1[CH:7]=[CH:2][CH:3]=[N:19][C:5]=1[N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]=2[N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 27831712-Bromo-5-fluoropyridineHCID 904095831-(5-Fluoropyridin-2-yl)-1H-imidazo[4,5-c]pyridine

Product 1

HCID 904088391-(Pyrimidin-2-yl)-1H-imidazo[4,5-c]pyridine

Procedure

Intermediate 5 was prepared in a manner analogous to Intermediate 1, substituting 2-bromopyrimidine for 2-bromo-5-fluoropyridine. MS (ESI): mass calculated for C10H7N5, 198.07. m/z found 199.1 [M+H]+.

Sources & evidence

ORD record
ord-4b171d88d45446f4b008ecc21e678c0c
Source dataset
uspto-grants-2015_06
Patent number
US09066946B2

Reaction notes

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