2,3-Dichlorobenzoic acid → (2,3-Dichlorophenyl)(1-phenyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone

HRID 2177562Notes

Reaction equation

HRID 2177562 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.Cl[C:13]1[C:21](C(F)(F)F)=[CH:20][CH:19]=[CH:18][C:14]=1C(O)=O.N1C=CC=CC=1[N:32]1[C:40]2[CH:39]=[CH:38][N:37]=[CH:36][C:35]=2[N:34]=[CH:33]1>>[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:37]1[CH2:38][CH2:39][C:40]2[N:32]([C:13]3[CH:14]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:33]=[N:34][C:35]=2[CH2:36]1)=[O:6]

Participants

4

Reactant 3

HCID 57652,3-Dichlorobenzoic acidHCID 27366772-Chloro-3-(trifluoromethyl)benzoic acidHCID 904094861-(Pyridin-2-yl)-1H-imidazo[4,5-c]pyridine

Product 1

HCID 86271660(2,3-Dichlorophenyl)(1-phenyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone

Procedure

Example 3 was made in a manner analogous with Example 1 substituting 2,3-dichlorobenzoic acid for 2-chloro-3-trifluoromethyl benzoic acid in Step C and substituting Intermediate 2 for Intermediate 3 in Step A.

Sources & evidence

ORD record
ord-b667bfe8a3a6499e90edc287a4377e1b
Source dataset
uspto-grants-2015_06
Patent number
US09066946B2

Reaction notes

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