Acetic Acid → HCID 90408675, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-(5-fluoropyrimidin-2-yl)-2-methylpyridine-3,4-diamine (0.50 g, 2.28 mmol) in THF (15 ml) and HOAc (0.14 ml, 2.51 mmol) was treated with t-butyl nitrite (0.45 ml, 3.42 mmol) and heated to 100° C. for 90 min. The reaction was concentrated, diluted with 1N NaHCO3, and extracted with DCM (50 mL×3). The organic layers were combined, dried (Na2SO4), and concentrated. Chromatography of the resulting residue (SiO2; EtOAc:Hex) gave the title compound (0.40 g, 77%). MS (ESI): mass calcd. for C10H7FN6, 230.07. m/z found, 231.1 [M+H]+.

Provenance & Evidence