HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 3-nitro-N-phenylpyridin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-nitro-N-phenylpyridin-4-amine | HCID 612005 | 93% |
Reaction Steps
To a mixture of 2-chloro-3-nitropyridine (15.8 g, 100 mmol) and aniline (11.1 g, 120 mmol) in dioxane (150 mL) was added was added K2CO3 (39 g, 120 mmol). The reaction was heated to reflux for 10 h and then purified by silica gel chromatography using petroleum etherethyl acetate to provide the product as a yellow solid (20 g, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09066946B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-8612844333f5423ba7139796c477b82e |
| Source note | uspto-grants-2015_06 |