Ammonium formate → HCID 90409398, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product of Example 238, Step 2 (200 mg, 0.49 mmol) in MeOH (2 mL) was added Pd/C (52 mg, 0.049 mmol) and ammonium formate (93 mg, 1.45 mmol). The reaction vessel was sealed and heated 80° C. for 16 h. The reaction mixture was then filtered through Celite, concentrated and purified on silica gel with 0-2% NH3 MeOH/CH2Cl2 to afford the title compound (93 mg, 46%). MS (ESI) mass calcd. C23H27FN4O2, 410.2. m/z found, 411.20 [M+H]+.

Provenance & Evidence