HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → HCID 90408929, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 2-Aminopyridine | HCID 10439 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 4-Chloro-3-nitropyridine | HCID 2735781 | — |
| Reactant | 4-Chloro-2,6-dimethyl-3-nitropyridine | HCID 10702725 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 90408929 | HCID 90408929 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 17, Step 1 through Intermediate 19, Step 3. In the synthesis of Intermediate 17, Step 1 Pd(OAc)2 and BINAP were eliminated and these substitutions were made: 4-chloro-2,6-dimethyl-3-nitropyridine for 4-chloro-3-nitropyridine, aniline for 2-aminopyridine, NaH for K2CO3, and THF for toluene, and the reaction was carried out for 24 h at room temperature. MS (ESI) mass calcd. C13H12N4, 224.1. m/z found, 225.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09066946B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-f4e48d0dd992451e8ba820eac17b4beb |
| Source note | uspto-grants-2015_06 |