HCID 178494163, compound → HCID 178494166, compound

HRID 2177665Notes

Reaction equation

HRID 2177665 reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:10]=[C:11]([NH:14][C:15]3[CH:20]=[N:19][CH:18]=[C:17]([O:21][C@@H:22]4[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]4)[N:16]=3)[NH:12][N:13]=2)=[CH:7][CH:6]=[C:5]([CH3:28])[N:4]=1>O.C(O)C>[OH2:2].[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:10]=[C:11]([NH:14][C:15]3[CH:20]=[N:19][CH:18]=[C:17]([O:21][C@@H:22]4[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]4)[N:16]=3)[NH:12][N:13]=2)=[CH:7][CH:6]=[C:5]([CH3:28])[N:4]=1

Participants

3

Reactant 1

HCID 178494163HCID 178494163, compound

Product 1

HCID 178494166HCID 178494166, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

Suspend (R)-[5-(2-methoxy-6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-[6-(piperidin-3-yloxy)-pyrazin-2-yl]-amine (52.1 mg; ES/MS m/z 382.2 [M+H]+) in 5.95 water-ethanol mixture (10 mL) and slurry at ambient temperature for 48 hours. A white crystalline solid is recovered by vacuum filtration.

Workup

  1. filtrationA white crystalline solid is recovered by vacuum filtration

Sources & evidence

ORD record
ord-d66c33a29ae9486da6ce78d0f3300d8a
Source dataset
uspto-grants-2015_06
Patent number
US09067920B2

Reaction notes

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