HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 6-(Benzenesulphonylmethyl)-2-methoxy-3-propylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-propylbenzoate | HCID 67107457 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(Benzenesulphonylmethyl)-2-methoxy-3-propylbenzoic acid | HCID 52913863 | 76.3% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
Lithium hydroxide (1M aqueous solution, 0.45 ml) was added to a solution of ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-propylbenzoate (Intermediate 24, 0.034 g) in dioxane and the solution was stirred and heated in the microwave at 160° C. for 15 minutes. The cooled solution was acidified by addition of formic acid and then purified by preparative HPLC (C18) eluting with a mixture of methanol and water containing 0.1% formic acid to give 6-(benzenesulphonylmethyl)-2-methoxy-3-propylbenzoic acid (0.024 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067905B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d5378df8d4da434fbddd918c838db639 |
| Source note | uspto-grants-2015_06 |