Lithium Hydroxide → HCID 52914640, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 6-benzenesulphonylmethyl-2-methoxy-3-(thiazol-2-yl)benzoate (Intermediate 34, 0.1 g) and lithium hydroxide (1M aqueous solution, 1.25 ml) in methanol (2 ml) was stirred and heated at 80° C. for 2 hours. The solution was evaporated to dryness and the residue was purified by HPLC (C18) eluting with a mixture of methanol and water containing 0.1% formic acid, with a gradient of 4-98%. The resultant gum was triturated with ether and the solid was collected by filtration to give 6-(benzenesulphonylmethyl)-2-methoxy-3-(thiazol-2-yl)benzoic acid (0.025 g) as a pale pink solid.

Provenance & Evidence