Hydrochloric Acid → HCID 52914286, compound

Participants

Reaction Steps

A mixture of ethyl 6-(benzenesulphonylmethyl)-3-(isoxazol-3-yl)-2-methoxybenzoate (Intermediate 47, 0.03 g), lithium hydroxide (1M aqueous solution, 0.4 ml) and dioxane (1 ml) was stirred at room temperature overnight then heated at 40° C. for 8 hours. It was left to stand at room temperature overnight then heated at 60° C. for 6 hours. The resultant mixture was acidified by addition of concentrated hydrochloric acid followed by addition of isopropanol (˜0.5 ml). The mixture was purified by preparative HPLC (C18), eluting with a mixture of methanol and water containing 0.1% formic acid with a gradient of 40-98% to give 6-(benzenesulphonylmethyl)-3-(isoxazol-3-yl)-2-methoxybenzoic acid (0.02 g) as a clear glass.

Provenance & Evidence