Methyl 6-[2-(2-diethylaminomethylazetidin-1-yl)benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoate → 6-[2-(2-Diethylaminomethylazetidin-1-yl)-benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoic acid

HRID 2177684Notes

Reaction equation

HRID 2177684 reaction equation
C1(S(CC2C(C(O)=O)=C(OCCN(C(OC(C)(C)C)=O)C)C(C3C=COC=3)=CC=2)(=O)=O)C=CC=CC=1.[CH2:37]([N:39]([CH2:42][CH:43]1[CH2:46][CH2:45][N:44]1[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=1[S:53]([CH2:56][C:57]1[C:62]([C:63]([O:65]C)=[O:64])=[C:61]([O:67][CH3:68])[C:60]([C:69]2[CH:73]=[CH:72][O:71][CH:70]=2)=[CH:59][CH:58]=1)(=[O:55])=[O:54])[CH2:40][CH3:41])[CH3:38]>>[CH2:37]([N:39]([CH2:42][CH:43]1[CH2:46][CH2:45][N:44]1[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=1[S:53]([CH2:56][C:57]1[C:62]([C:63]([OH:65])=[O:64])=[C:61]([O:67][CH3:68])[C:60]([C:69]2[CH:73]=[CH:72][O:71][CH:70]=2)=[CH:59][CH:58]=1)(=[O:54])=[O:55])[CH2:40][CH3:41])[CH3:38]

Participants

3

Reactant 2

HCID 67107568Methyl 6-[2-(2-diethylaminomethylazetidin-1-yl)benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoate2×HCID 67107892HCID 67107892, compound

Product 1

HCID 529135326-[2-(2-Diethylaminomethylazetidin-1-yl)-benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoic acid

Procedure

Prepared by proceeding in a similar manner to Intermediate 124, starting from methyl 6-[2-(2-diethylaminomethylazetidin-1-yl)benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoate (Intermediate 205) as a white solid

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e499d0e4c95a478a89c1190df965a80b
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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