Sodium Hydroxide → 3-Amino-6-bromopyrazine-2-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of the product of step (iii) (200 g, 0.86 mol) in MeOH (500 mL) was added 5 N—NaOH (500 mL) slowly. The resulting mixture was stirred at 50° C. for 3 hours. MeOH was removed under a reduced pressure and water (300 mL) added to the reaction mixture. The solution was acidified to pH 3 with 6N—HCl. The solution was extracted with EtOAc and washed with water. The combined organic extract was dried over Na2SO4, filtered and evaporated to dryness to afford the subtitle compound (iv) as a brown yellow solid (180 g).

Provenance & Evidence