Cesium carbonate → Ethyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2-(2-hydroxyethoxy)benzoate

Participants

Reaction Steps

A solution of 2-bromoethanol (0.034 g) in DMF (1 ml) was added to a stirred mixture of ethyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2-hydroxybenzoate (Intermediate 36, 0.1 g) and cesium carbonate (0.127 g) in DMF (1 ml). The resultant mixture was stirred at room temperature for 3 hours. Further 2-bromoethanol (0.017 g) was added and the mixture was stirred at room temperature for a further 3 days. Cesium carbonate (0.085 g) and 2-bromoethanol (0.024 g) were added and the mixture was stirred for 1 hour. 2-Bromoethanol (0.015 g) was added and the mixture was stirred for a further 1 hour. The resultant mixture was partitioned between ethyl acetate and water and the aqueous layer was further extracted with ethyl acetate. The combined organic layers were washed with water, dried (Na2SO4) and filtered. The filtrate was evaporated to dryness and the residue was purified by chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane with a gradient of 30-50%. The product was again purified by chromatography on silica, eluting with a mixture of ethyl acetate and pentane with a gradient of 25-30% to give ethyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2-(2-hydroxyethoxy)benzoate (0.037 g) as a white solid.

Provenance & Evidence