3-Pyridinylboronic acid → Ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-(pyrid-3-yl)benzoate

HRID 2177714Notes

Reaction equation

HRID 2177714 reaction equation
O1[CH:5]=[CH:4][C:3]([C:6]2[C:7]([O:28][CH3:29])=[C:8]([C:14]([CH2:17][S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3C)(=[O:20])=[O:19])=[CH:15][CH:16]=2)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:2]1.C1(S(CC2C(C(OCC)=O)=C(OC)C(Br)=CC=2)(=O)=O)C=CC=CC=1.[N:54]1C=CC=C(B(O)O)[CH:55]=1>>[C:21]1([S:18]([CH2:17][C:14]2[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([O:28][CH3:29])[C:6]([C:3]3[CH:2]=[N:54][CH:55]=[CH:5][CH:4]=3)=[CH:16][CH:15]=2)(=[O:19])=[O:20])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 27343783-Pyridinylboronic acidHCID 67107394Ethyl 6-(benzenesulphonylmethyl)-3-bromo-2-methoxybenzoate2×HCID 67107552Ethyl 3-(furan-3-yl)-2-methoxy-6-(2-methylbenzenesulphonylmethyl)benzoate

Product 1

HCID 67107345Ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-(pyrid-3-yl)benzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 28, starting from ethyl 6-benzenesulphonylmethyl-3-bromo-2-methoxybenzoate (Intermediate 61) and 3-pyridylboronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3f844c28b7ae44f7870f98984051bb43
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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