HCID 67107992, compound → HCID 67107596, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 6-(benzenesulphonylmethyl)-3-(5-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methoxybenzoate (Intermediate 49, 0.041 g) in ethanol (3 ml) was stirred and heated in the microwave at 140° C. for 15 minutes then at 160° C. for 75 minutes. After cooling, the solution was evaporated to dryness and the residue was purified by chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane with a gradient of 0-50% to give ethyl 6-(benzenesulphonylmethyl)-3-(isoxazol-3-yl)-2-methoxybenzoate (0.03 g) as a gum.

Provenance & Evidence