反应详情

Aluminium chloride (0.7 g) was added to a stirred solution of methyl 3-bromo-6-(3-chlorobenzenesulphonylmethyl)-2-methoxybenzoate (Intermediate 68, 0.76 g) and N,N-dimethylaniline (1.27 g) in DCM (8 ml) and the resultant mixture was stirred for 30 minutes. The mixture was partitioned between ethyl acetate and hydrochloric acid (1M) and the organic layer was washed with sodium bicarbonate (saturated aqueous solution), dried (Na2SO4) and filtered. The filtrate was evaporated to dryness and the residue was triturated with ether. The solid was collected by filtration to give methyl 3-bromo-6-(3-chlorobenzenesulphonylmethyl)-2-hydroxybenzoate (0.61 g) as a white solid.

1. customThe mixture was partitioned between ethyl acetate and hydrochloric acid (1M)
2. washthe organic layer was washed with sodium bicarbonate (saturated aqueous solution)
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customThe filtrate was evaporated to dryness
6. customthe residue was triturated with ether
7. filtrationThe solid was collected by filtration