Thiophenol → Methyl 5-bromo-2-(phenylthiomethyl)benzoate

HRID 2177745Notes

Reaction equation

HRID 2177745 reaction equation
BrC1C(OC)=C(C=CC=1C[S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1C)C(OCC)=O.[Br:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:35]Br)=[C:29]([CH:34]=1)[C:30]([O:32][CH3:33])=[O:31].C1(S)C=CC=CC=1>>[Br:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:35][S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:29]([CH:34]=1)[C:30]([O:32][CH3:33])=[O:31]

Participants

4

Reactant 3

HCID 7969ThiophenolHCID 12929136Methyl 5-bromo-2-(bromomethyl)benzoateHCID 67107587Ethyl 3-bromo-2-methoxy-(2-methylphenylthiomethyl)benzoate

Product 1

HCID 67107602Methyl 5-bromo-2-(phenylthiomethyl)benzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 77, starting from methyl 5-bromo-2-bromomethylbenzoate (prepared according to Lartia et al, J Org Chem, 2008, 73, 1732) and thiophenol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fade0985a8f845f8b3dde24095ff2041
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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