Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate → Methyl 3-bromo-2-methoxy-6-(pyrid-2-ylthiomethyl)benzoate

HRID 2177750Notes

Reaction equation

HRID 2177750 reaction equation
BrC1C(O)=C(C(CSC2C=CC=CC=2OC)=CC=1)C(OC)=O.[Br:23][C:24]1[C:25]([O:36][CH3:37])=[C:26]([C:31]([CH2:34]Br)=[CH:32][CH:33]=1)[C:27]([O:29][CH3:30])=[O:28].[N:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[SH:44]>>[Br:23][C:24]1[C:25]([O:36][CH3:37])=[C:26]([C:31]([CH2:34][S:44][C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][N:38]=2)=[CH:32][CH:33]=1)[C:27]([O:29][CH3:30])=[O:28]

Participants

4

Reactant 3

HCID 66685947Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate2×HCID 67107461Methyl 3-bromo-2-hydroxy-6-(2-methoxyphenylthiomethyl)benzoateHCID 178418616HCID 178418616, compound

Product 1

HCID 67107692Methyl 3-bromo-2-methoxy-6-(pyrid-2-ylthiomethyl)benzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 82, starting from methyl 3-bromo-6-bromomethylbenzoate (Intermediate 89) and 2-pyridinethiol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ad5916915c644af1815d170ed50dbb13
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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