Sodium pyridine-3-sulphonate → HCID 67107530, compound

HRID 2177753Notes

Reaction equation

HRID 2177753 reaction equation
[Br:1][C:2]1[C:3]([O:24][CH3:25])=[C:4]([C:10]([CH2:13][S:14]([C:17]2[CH:22]=C[C:20](F)=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].BrC1C(OC)=C(C(CSC2C=CC=CC=2)=CC=1)C(OCC)=O.[N:48]1C=CC=C(S([O-])(=O)=O)C=1.[Na+]>>[Br:1][C:2]1[C:3]([O:24][CH3:25])=[C:4]([C:10]([CH2:13][S:14]([C:17]2[CH:22]=[N:48][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

4

Reactant 3

HCID 23677935Sodium pyridine-3-sulphonateHCID 67107500HCID 67107500, compound2×HCID 67107891HCID 67107891, compound

Product 1

HCID 67107530HCID 67107530, compound

Procedure

Prepared by proceeding in a similar manner to Intermediate 85, starting from ethyl 3-bromo-6-bromomethyl-2-methoxybenzoate (Intermediate 87) and sodium 3-pyridinesulphonate (prepared according to Crowell et al, J. med. Chem., 1989, 32, 2436).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8ea52cda2e5b4bb6aabe529dd8f2ec36
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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