Furan-3-boronic acid → Methyl 3-(furan-3-yl)-2-methoxy-6-(3-methoxybenzene-sulphonylmethyl)benzoate

HRID 2177762Notes

Reaction equation

HRID 2177762 reaction equation
C1(S(CC2C(C(OCC)=O)=C(O)C([C:23]3[CH:27]=[CH:26][O:25][CH:24]=3)=CC=2)(=O)=O)C=CC=CC=1.Br[C:29]1[C:30]([O:51][CH3:52])=[C:31]([C:36]([CH2:39][S:40]([C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([O:49][CH3:50])[CH:44]=2)(=[O:42])=[O:41])=[CH:37][CH:38]=1)[C:32]([O:34][CH3:35])=[O:33].O1C=CC(B(O)O)=C1>>[O:25]1[CH:26]=[CH:27][C:23]([C:29]2[C:30]([O:51][CH3:52])=[C:31]([C:36]([CH2:39][S:40]([C:43]3[CH:48]=[CH:47][CH:46]=[C:45]([O:49][CH3:50])[CH:44]=3)(=[O:41])=[O:42])=[CH:37][CH:38]=2)[C:32]([O:34][CH3:35])=[O:33])=[CH:24]1

Participants

4

Reactant 3

HCID 2734358Furan-3-boronic acidHCID 67107629Ethyl 6-benzenesulphonylmethyl-3-(furan-3-yl)-2-hydroxybenzoateHCID 67107955Methyl 3-bromo-2-methoxy-6-(3-methoxybenzenesulphonylmethyl)benzoate2×

Product 1

HCID 67107512Methyl 3-(furan-3-yl)-2-methoxy-6-(3-methoxybenzene-sulphonylmethyl)benzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 36, starting from methyl 3-bromo-2-methoxy-6-(3-methoxybenzenesulphonylmethyl)benzoate (Intermediate 101) and furan-3-yl boronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6410de8fe8024312b8a010049bac4bd3
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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