tert-butyl N-(3-bromopropyl)carbamate → Methyl 6-(benzenesulphonylmethyl)-2-(3-t-butoxycarbonylaminopropoxy)-3-(furan-3-yl)benzoate

HRID 2177772Notes

Reaction equation

HRID 2177772 reaction equation
[C:1]1([S:7]([CH2:10][C:11]2[C:16]([C:17]([O:19][CH2:20]C)=[O:18])=[C:15]([O:22][CH2:23][CH2:24]NC(OC(C)(C)C)=O)[C:14]([C:33]3[CH:37]=[CH:36][O:35][CH:34]=3)=[CH:13][CH:12]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(S(CC2C(C(OC)=O)=C(O)C(C3C=COC=3)=CC=2)(=O)=O)C=CC=CC=1.[C:64]([O:68][C:69]([NH:71][CH2:72]CCBr)=[O:70])([CH3:67])([CH3:66])[CH3:65]>>[C:1]1([S:7]([CH2:10][C:11]2[C:16]([C:17]([O:19][CH3:20])=[O:18])=[C:15]([O:22][CH2:23][CH2:24][CH2:72][NH:71][C:69]([O:68][C:64]([CH3:67])([CH3:66])[CH3:65])=[O:70])[C:14]([C:33]3[CH:37]=[CH:36][O:35][CH:34]=3)=[CH:13][CH:12]=2)(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 4460490tert-butyl N-(3-bromopropyl)carbamateHCID 67107565Ethyl 6-(benzenesulphonylmethyl)-2-[2-(t-butoxycarbonyl)aminoethoxy]-3-(furan-3-yl)benzoateHCID 67107618Methyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2-hydroxybenzoate2×

Product 1

HCID 67107554Methyl 6-(benzenesulphonylmethyl)-2-(3-t-butoxycarbonylaminopropoxy)-3-(furan-3-yl)benzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 10, starting from methyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2-hydroxybenzoate (Intermediate 114) and 3-(t-butoxycarbonylamino)propyl bromide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1eba648642674b86936fb5bae68ac524
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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