Furan-3-boronic acid → Methyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2-hydroxybenzoate

HRID 2177777Notes

Reaction equation

HRID 2177777 reaction equation
[C:1]1([S:7]([CH2:10][C:11]2[C:16]([C:17]([O:19][CH2:20]C)=[O:18])=[C:15]([O:22]C)[C:14]([C:24]3[CH:28]=[CH:27]NN=3)=[CH:13][CH:12]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(S(CC2C([C:45](OC)=[O:46])=C(O)C(Br)=CC=2)(=O)=O)C=CC=CC=1.O1C=CC(B(O)O)=C1>>[C:1]1([S:7]([CH2:10][C:11]2[C:16]([C:17]([O:19][CH3:20])=[O:18])=[C:15]([OH:22])[C:14]([C:24]3[CH:28]=[CH:27][O:46][CH:45]=3)=[CH:13][CH:12]=2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 2734358Furan-3-boronic acidHCID 66685467Methyl 6-(benzenesulfonylmethyl)-3-bromo-2-hydroxybenzoate2×HCID 178469414HCID 178469414, compound

Product 1

HCID 67107618Methyl 6-(benzenesulphonylmethyl)-3-(furan-3-yl)-2-hydroxybenzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 45, starting from methyl 6-(benzenesulphonylmethyl)-3-bromo-2-hydroxybenzoate (Intermediate 115) and furan-3-yl boronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4810575612c34d368aa75fbf2008e5a0
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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