4-Fluorothiophenol → Methyl 3-bromo-6-(4-fluorophenylthiomethyl)-3-methoxybenzoate

HRID 2177781Notes

Reaction equation

HRID 2177781 reaction equation
[Br:1][C:2]1[C:3](OC)=[C:4]([C:10]([CH2:13][S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8]C)=[O:6].BrC1C([O:36][CH3:37])=C(C(CBr)=CC=1)C(OC)=O.[F:38]C1C=CC(S)=CC=1>>[Br:1][C:2]1([O:36][CH3:37])[CH:12]=[CH:11][C:10]([CH2:13][S:14][C:15]2[CH:16]=[CH:17][C:18]([F:38])=[CH:19][CH:20]=2)=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH2:3]1

Participants

4

Reactant 3

HCID 677894-FluorothiophenolHCID 66685947Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate2×HCID 67107500HCID 67107500, compound

Product 1

HCID 67107753Methyl 3-bromo-6-(4-fluorophenylthiomethyl)-3-methoxybenzoate

Procedure

Prepared by proceeding in a manner similar to Intermediate 73, starting from methyl 3-bromo-6-bromomethyl-2-methoxybenzoate (Intermediate 89) and 4-fluorothiophenol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2980e5a516a34cce8efcaed321dc6def
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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