Lithium hydroxide, monohydrate → HCID 67107892, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 6-(benzenesulphonylmethyl)-2-[2-(N-t-butoxycarbonyl-N-methylamino)ethoxy]-3-(furan-3-yl)benzoate (Intermediate 125, 0.054 g) was added to a solution of lithium hydroxide monohydrate (0.034 g) in water (0.3 ml) and dioxane (1 ml) and the mixture was stirred and heated at 130° C. for 30 minutes. The reaction mixture was cooled to room temperature, and partitioned between water and ethyl acetate. The aqueous layer was acidified with formic acid and extracted with ethyl acetate, dried (Na2SO4) and filtered. The filtrate was evaporated to dryness to give 6-(benzenesulphonylmethyl)-2-[2-(N-t-butoxycarbonyl-N-methylamino)ethoxy]-3-(furan-3-yl)benzoic acid (0.043 g).

Provenance & Evidence