N,N-Diethylethylenediamine → Methyl 6-[2-(2-diethylaminoethylamino)benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoate

HRID 2177808Notes

Reaction equation

HRID 2177808 reaction equation
C(N(CC)C[CH2:5][CH2:6][NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14]([CH2:17][C:18]1[C:23]([C:24]([O:26][CH3:27])=[O:25])=[C:22]([O:28][CH3:29])[C:21]([C:30]2[CH:34]=[CH:33][O:32][CH:31]=2)=[CH:20][CH:19]=1)(=[O:16])=[O:15])C.FC1C=CC=CC=1S(CC1C(C(OC)=O)=C(OC)C(C2C=COC=2)=CC=1)(=O)=O.[CH2:65]([N:67](CC)[CH2:68][CH2:69]N)[CH3:66]>>[CH2:65]([N:67]([CH2:68][CH3:69])[CH2:5][CH2:6][NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14]([CH2:17][C:18]1[C:23]([C:24]([O:26][CH3:27])=[O:25])=[C:22]([O:28][CH3:29])[C:21]([C:30]2[CH:34]=[CH:33][O:32][CH:31]=2)=[CH:20][CH:19]=1)(=[O:16])=[O:15])[CH3:66]

Participants

4

Reactant 3

HCID 60993N,N-DiethylethylenediamineHCID 67107606Methyl 6-(2-fluorobenzenesulphonylmethyl)-3-(furan-3-yl)-2-methoxybenzoate2×HCID 67107645Methyl 6-[2-(3-diethylaminopropylamino)benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoate

Product 1

HCID 67107540Methyl 6-[2-(2-diethylaminoethylamino)benzenesulphonylmethyl]-3-(furan-3-yl)-2-methoxybenzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 192, starting from methyl 6-(2-fluorobenzenesulphonylmethyl)-3-(furan-3-yl)-2-methoxybenzoate (Intermediate 96) and N,N,-diethylethylenediamine, as brown solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-67197ca6818444b58f8781ca53e0e08e
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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