Cyclohexanethiol → Methyl 3-bromo-6-(cyclohexylthiomethyl)-2-methoxybenzoate

HRID 2177813Notes

Reaction equation

HRID 2177813 reaction equation
[Br:1][C:2]1[C:3]([OH:22])=[C:4]([C:9]([CH2:12][S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2OC)=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].Br[C:24]1C(OC)=C(C(CBr)=CC=1)C(OC)=O.C1(S)CCCCC1>>[Br:1][C:2]1[C:3]([O:22][CH3:24])=[C:4]([C:9]([CH2:12][S:13][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

Participants

4

Reactant 3

HCID 15290CyclohexanethiolHCID 66685947Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate2×HCID 67107461Methyl 3-bromo-2-hydroxy-6-(2-methoxyphenylthiomethyl)benzoate

Product 1

HCID 67107734Methyl 3-bromo-6-(cyclohexylthiomethyl)-2-methoxybenzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 82, starting from methyl 3-bromo-6-bromomethyl-2-methoxybenzoate (Intermediate 89) and cyclohexanethiol and used without further purification.

Workup

  1. customPrepared
  2. customused without further purification

Sources & evidence

ORD record
ord-51130e68260e45f3a5a3b1d0cfe11cd8
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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