2-Bromo-4-fluorobenzene-1-thiol → Methyl 3-bromo-6-(2-bromo-4-fluorophenylthiomethyl)-2-methoxybenzoate

HRID 2177817Notes

Reaction equation

HRID 2177817 reaction equation
BrC1C(OC)=C(C=CC=1CSC1C=CC=CC=1C)C(OCC)=O.[Br:24][C:25]1[C:26]([O:37][CH3:38])=[C:27]([C:32]([CH2:35]Br)=[CH:33][CH:34]=1)[C:28]([O:30][CH3:31])=[O:29].[Br:39][C:40]1[CH:45]=[C:44]([F:46])[CH:43]=[CH:42][C:41]=1[SH:47]>>[Br:24][C:25]1[C:26]([O:37][CH3:38])=[C:27]([C:32]([CH2:35][S:47][C:41]2[CH:42]=[CH:43][C:44]([F:46])=[CH:45][C:40]=2[Br:39])=[CH:33][CH:34]=1)[C:28]([O:30][CH3:31])=[O:29]

Participants

4

Reactant 3

HCID 265970852-Bromo-4-fluorobenzene-1-thiolHCID 66685947Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate2×HCID 67107587Ethyl 3-bromo-2-methoxy-(2-methylphenylthiomethyl)benzoate

Product 1

HCID 67107561Methyl 3-bromo-6-(2-bromo-4-fluorophenylthiomethyl)-2-methoxybenzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 77, starting from methyl 3-bromo-6-bromomethyl-2-methoxybenzoate (Intermediate 89) and 2-bromo-4-fluorothiophenol and used without further characterization.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a0ce1f4e3c434d6daaca79ea07d5e62d
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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