4-Hydroxypyrrolidine → HCID 67107769, compound

HRID 2177819Notes

Reaction equation

HRID 2177819 reaction equation
[Br:1][C:2]1[C:3]([O:22][CH3:23])=[C:4]([C:9]([CH2:12][S:13]([N:16]2[CH2:21]C[CH2:19][CH2:18][CH2:17]2)(=[O:15])=[O:14])=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[Na+].BrC1C=CC(CS([O-])(=O)=[O:34])=C(C(OC)=O)C=1OC.N1CCC(O)C1>>[Br:1][C:2]1[C:3]([O:22][CH3:23])=[C:4]([C:9]([CH2:12][S:13]([N:16]2[CH2:17][CH2:18][CH:19]([OH:34])[CH2:21]2)(=[O:14])=[O:15])=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

Participants

4

Reactant 3

HCID 982104-HydroxypyrrolidineHCID 69915004HCID 69915004, compoundHCID 87271490HCID 87271490, compound2×

Product 1

HCID 67107769HCID 67107769, compound

Procedure

Prepared as a colourless oil by proceeding in a similar manner to Intermediate 147, starting from methyl (4-bromo-3-methoxy-2-methoxycarbonylphenyl)methanesulphonic acid sodium salt (Intermediate 148, 0.134 g) and 3-pyrrolidinol (0.12 g).

Workup

  1. customPrepared as a colourless oil

Sources & evidence

ORD record
ord-1e2a3c065d044d979ab50d20c99054d5
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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