Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate → Methyl 3-bromo-6-(2-hydroxyethylthiomethyl)-2-methoxybenzoate

HRID 2177826Notes

Reaction equation

HRID 2177826 reaction equation
[Br:1][C:2]1[C:3]([OH:22])=[C:4]([C:9]([CH2:12][S:13][C:14]2C=CC=C[C:15]=2[O:20]C)=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].Br[C:24]1C(OC)=C(C(CBr)=CC=1)C(OC)=O>>[Br:1][C:2]1[C:3]([O:22][CH3:24])=[C:4]([C:9]([CH2:12][S:13][CH2:14][CH2:15][OH:20])=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 2

HCID 66685947Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate2×HCID 67107461Methyl 3-bromo-2-hydroxy-6-(2-methoxyphenylthiomethyl)benzoate

Product 1

HCID 67107555Methyl 3-bromo-6-(2-hydroxyethylthiomethyl)-2-methoxybenzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 82, starting from methyl 3-bromo-6-bromomethyl-2-methoxybenzoate (Intermediate 89) and 2-mercaptolethanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f72a155729ab42549c1d803c79db4bb0
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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