Ethyl 6-benzenesulphonylmethyl-3-(furan-3-yl)-2-hydroxybenzoate → Methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-(furan-3-yl)-2-methoxybenzoate

HRID 2177827Notes

Reaction equation

HRID 2177827 reaction equation
C1(S(CC2C(C(OCC)=O)=C(O)C([C:23]3[CH:27]=[CH:26][O:25][CH:24]=3)=CC=2)(=O)=O)C=CC=CC=1.[CH:28]12[N:34]([S:35]([CH2:38][C:39]3[C:44]([C:45]([O:47][CH3:48])=[O:46])=[C:43]([O:49][CH3:50])[C:42](Br)=[CH:41][CH:40]=3)(=[O:37])=[O:36])[CH:31]([CH2:32][CH2:33]1)[CH2:30][CH2:29]2>>[CH:28]12[N:34]([S:35]([CH2:38][C:39]3[C:44]([C:45]([O:47][CH3:48])=[O:46])=[C:43]([O:49][CH3:50])[C:42]([C:23]4[CH:27]=[CH:26][O:25][CH:24]=4)=[CH:41][CH:40]=3)(=[O:37])=[O:36])[CH:31]([CH2:32][CH2:33]1)[CH2:30][CH2:29]2

Participants

3

Reactant 2

HCID 67107629Ethyl 6-benzenesulphonylmethyl-3-(furan-3-yl)-2-hydroxybenzoateHCID 67107913Methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate2×

Product 1

HCID 67107950Methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-(furan-3-yl)-2-methoxybenzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 36, starting from methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate (Intermediate 177) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0d9e0e5c2a0c4059b0dd100a41fbc33a
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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