8-Azabicyclo(3.2.1)octane → HCID 67107760, compound

HRID 2177833Notes

Reaction equation

HRID 2177833 reaction equation
[CH:1]12[N:7]([S:8]([CH2:11][C:12]3[C:17]([C:18]([O:20][CH3:21])=[O:19])=[C:16]([O:22][CH3:23])[C:15]([Br:24])=[CH:14][CH:13]=3)(=[O:10])=[O:9])[CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Na+].Br[C:27]1C=CC(CS([O-])(=O)=O)=C(C(OC)=O)C=1OC.C12NC(CC1)CCC2>>[CH:1]12[N:7]([S:8]([CH2:11][C:12]3[C:17]([C:18]([O:20][CH3:21])=[O:19])=[C:16]([O:22][CH3:23])[C:15]([Br:24])=[CH:14][CH:13]=3)(=[O:9])=[O:10])[CH:4]([CH2:3][CH2:2]1)[CH2:27][CH2:5][CH2:6]2

Participants

4

Reactant 3

HCID 1360978-Azabicyclo(3.2.1)octaneHCID 67107913Methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoateHCID 87271490HCID 87271490, compound2×

Product 1

HCID 67107760HCID 67107760, compound

Procedure

Prepared by proceeding in a similar manner to Intermediate 177, starting from methyl (4-bromo-3-methoxy-2-methoxycarbonylphenyl)-methanesulphonic acid sodium salt (Intermediate 148) and 8-azabicyclo[3.2.1]octane, as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7f326912f38a473f89d6eb55d3523902
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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