Hydrochloric Acid → HCID 67107791, compound

Participants

Reaction Steps

A mixture of methyl 8-bromo-2-methylnaphthalene-1-carboxylate (Intermediate 191, 1.0 g), sodium methoxide (25% wt/solution in methanol, 5 g), copper iodide (0.37 g), and pyridine (13 ml) in methanol (13 ml) was stirred and heated at reflux for 3 days. After cooling, the mixture was diluted with water, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was separated, washed with 1M HCl and brine, dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue was purified by chromatography on silica eluting with a mixture of ethyl acetate and cyclohexane with a gradient of 0-25% to give methyl 8-methoxy-2-methylnaphthalene-1-carboxylate (0.33 g) as a lilac oil.

Provenance & Evidence