6-(Benzenesulphonylmethyl)-2-[2-(t-butoxycarbonylamino)ethylamino]-3-(furan-3-yl)benzoic acid → (Z)-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-hydroxybenzoic acid

HRID 2177840Notes

Reaction equation

HRID 2177840 reaction equation
C1(S(CC2C(C(O)=O)=C(NCCNC(OC(C)(C)C)=O)C(C3C=COC=3)=CC=2)(=O)=O)C=CC=CC=1.[CH2:36]([N:38]([CH2:69][CH3:70])[CH2:39]/[CH:40]=[CH:41]\[C:42]1[CH:47]=[C:46]([F:48])[CH:45]=[CH:44][C:43]=1[S:49]([CH2:52][C:53]1[C:58]([C:59]([O:61]C)=[O:60])=[C:57]([OH:63])[C:56]([C:64]2[CH:68]=[CH:67][O:66][CH:65]=2)=[CH:55][CH:54]=1)(=[O:51])=[O:50])[CH3:37]>>[CH2:69]([N:38]([CH2:36][CH3:37])[CH2:39]/[CH:40]=[CH:41]\[C:42]1[CH:47]=[C:46]([F:48])[CH:45]=[CH:44][C:43]=1[S:49]([CH2:52][C:53]1[C:58]([C:59]([OH:61])=[O:60])=[C:57]([OH:63])[C:56]([C:64]2[CH:68]=[CH:67][O:66][CH:65]=2)=[CH:55][CH:54]=1)(=[O:51])=[O:50])[CH3:70]

Participants

3

Reactant 2

HCID 671077416-(Benzenesulphonylmethyl)-2-[2-(t-butoxycarbonylamino)ethylamino]-3-(furan-3-yl)benzoic acidHCID 86677120(Z)-methyl 6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-hydroxybenzoate2×

Product 1

HCID 67108234(Z)-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-hydroxybenzoic acid

Procedure

Prepared by proceeding in a similar manner to Intermediate 121, starting from (Z)-methyl 6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-hydroxybenzoate (Intermediate 196).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fbbe90d258ca451b867d97c4a77497d7
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

Loading…