反应详情

Formaldehyde (0.138 ml) was added dropwise to a solution of 2-amino-6-(benzenesulphonylmethyl)-3-(furan-3-yl)benzoic acid (Intermediate 211, 0.116 g) in methanol (4 ml) at 60° C. and the resultant mixture was stirred at that temperature for 0.5 hours. After cooling, the mixture was filtered through a phase separator and the filtrate was evaporated to dryness. The residue was triturated with diethyl ether and the solid was collected by filtration to give 5-(benzenesulphonylmethyl)-8-(furan-3-yl)-1,2-dihydro-benzo[d][1,3]oxazin-4-one (0.118 g) as a white solid.

1. temperatureAfter cooling
2. filtrationthe mixture was filtered through a phase separator
3. customthe filtrate was evaporated to dryness
4. customThe residue was triturated with diethyl ether
5. filtrationthe solid was collected by filtration