HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → HCID 86661489, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 3-Amino-6-(4-(2-hydroxyethyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide | HCID 66678763 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86661489 | HCID 86661489 | 61.3% |
Reaction Steps
To a solution of the product of step (iii) (2.5 g, 7.5 mmol, 1.0 eq) and TEA (2.3 g, 22.5 mmol) in dry dichlormethane was added MsCl (1.7 g, 15 mmol). The reaction mixture was stirred at room temperature for 4 hours. The solvent was removed under reduced pressure and the residue purified by column to afford the subtitled compounds (1.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198285B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-e429fb112a0348e188e7e76f02a69e0c |
| Source note | uspto-grants-2012_06 |