2-Thiopheneacetic acid → 2-Thiopheneacetyl chloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(thiophen-2-yl)acetic acid (2 g, 14 mmol) in DCM (50 mL) was added dropwise SOCl2 (0.5 mL), the mixture was heated at 50° C. overnight. The reaction mixture was concentrated under reduced pressure to give compound 2-(thiophen-2-yl)acetyl chloride, which was used directly in the next step without further purification.

Provenance & Evidence