Morpholine → HCID 46901759, compound

HRID 217802Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[C:12]2[N:14]=[CH:15][CH:16]=[C:17]([O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[C:21]([F:33])[CH:20]=3)[C:11]2=[N:10][CH:9]=1>>[F:33][C:21]1[CH:20]=[C:19]([O:18][C:17]2[C:11]3[C:12](=[N:13][C:8]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[CH:9][N:10]=3)[N:14]=[CH:15][CH:16]=2)[CH:24]=[CH:23][C:22]=1[NH:25][C:26](=[O:32])[O:27][C:28]([CH3:30])([CH3:29])[CH3:31]

Participants

Reactant 2

HCID 8083Morpholine

HCID 46899947HCID 46899947, compound

Product 1

HCID 46901759HCID 46901759, compound

Procedure

Method D6 was used with morpholine and tert-butyl 4-(3-chloropyrido[2,3-b]pyrazin-8-yloxy)-2-fluorophenylcarbamate to give the title compound as a white solid. Yield: 117 mg (89%).

Sources & evidence

ORD record: ord-38074a7035c44b7f90e16ae871d4aea4
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08198279B2

Reaction notes

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