HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-1-chloro-2-fluorobenzene → 1-(4-Chloro-3-fluorophenyl)-2-phenylethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-1-chloro-2-fluorobenzene | HCID 2724690 | — |
| Reactant | 1-(3,5-Dichlorophenyl)-2-phenylethanone | HCID 2758146 | — |
| Product | 1-(4-Chloro-3-fluorophenyl)-2-phenylethanone | HCID 2757567 | 18.2% |
Reaction Steps
Prepared following the procedure described in Intermediate 13, starting from 4-bromo-1-chloro-2-fluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 16 (200 mg, yield 18.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067893B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-e911b924e7ba440785b66338823fb4b4 |
| Source note | uspto-grants-2015_06 |