1-Bromo-3,5-difluorobenzene → 3',5'-Difluoro-2-phenylacetophenone

HRID 2178036Notes

Reaction equation

HRID 2178036 reaction equation
ClC1C=C([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)C=C(Cl)C=1.Br[C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[CH:20]=1>>[F:26][C:21]1[CH:20]=[C:19]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:24]=[C:23]([F:25])[CH:22]=1

Participants

3

Reactant 2

HCID 1363131-Bromo-3,5-difluorobenzeneHCID 27581461-(3,5-Dichlorophenyl)-2-phenylethanone

Product 1

HCID 27583193',5'-Difluoro-2-phenylacetophenoneYield 10.3%

Procedure

Prepared following the procedure described in Intermediate 13, starting from 1-bromo-3,5-difluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 18 (100 mg, yield 10.3%).

Workup

  1. customPrepared
  2. customwas purified by column chromatography (PE:EtOAc=100:1)

Sources & evidence

ORD record
ord-fde73e07d37a46039d510173026ee8d6
Source dataset
uspto-grants-2015_06
Patent number
US09067893B2

Reaction notes

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