1-(1,1'-Biphenyl)-4-yl-2-phenylethan-1-one → 1-[4-(Morpholin-4-yl)phenyl]-2-phenylethanone

HRID 2178043Notes

Reaction equation

HRID 2178043 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C1(C2C=CC=CC=2)C=CC([C:20](=[O:28])[CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=CC=1>>[O:11]1[CH2:12][CH2:13][N:8]([C:5]2[CH:6]=[CH:7][C:2]([C:20](=[O:28])[CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:3][CH:4]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 748171-(1,1'-Biphenyl)-4-yl-2-phenylethan-1-oneHCID 116228514-(4-Bromophenyl)morpholine

Product 1

HCID 2696961-[4-(Morpholin-4-yl)phenyl]-2-phenylethanoneYield 36%

Procedure

Prepared from 4-(4-bromophenyl)morpholine following the procedure described in Intermediate 14, where the crude product was purified by column chromatography (PE:EtOAc=5:1) to afford Intermediate 25 (280 mg, yield 36%).

Workup

  1. customwas purified by column chromatography (PE:EtOAc=5:1)

Sources & evidence

ORD record
ord-f5d537b9d79b42fcb427c86d9f5b8856
Source dataset
uspto-grants-2015_06
Patent number
US09067893B2

Reaction notes

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